Protein Details: Acid-sensing ion channel 5
Protein ID
ICDB_Pro_1614
Protein Name
Acid-sensing ion channel 5
Gene Name
Asic5; Accn5; Blinac
Organism
Rattus norvegicus (Rat)
Length
495 amino acids
AlphaFoldDB
AF-Q9R0W5-F1-model_v4.pdb
Function
Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium; and is inhibited by amiloride.
Sequence
MEHTEKSKGPAEKGLLGKIRRYLSKRPLPSPTDRKKFDHDFAISTSFHGIHNIAQNQNKVRKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFLLPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYLFTSFYWVFIFFLLKILEMIQRTSPPQTV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Detected in brain; liver; duodenum; jejunum; ileum and testis
DOI ID
10.1111/j.1469-7793.1999.0323m.x
RefSeq
NP_071563.1